Method for promoting weight
and fat loss
Inventors:
McCarty; Mark F. (San Diego, CA); Gustin; John (Carlsbad, CA)
Abstract
A method for promoting weight and fat loss comprising administering to an
individual in need thereof hydroxycitrate, carnitine and an agent which promotes
the rapid intramitochondrial generation of oxaloacetate or induces endogenous
production of pyruvate. This method also promotes an increase in lean body mass.
FIELD OF THE INVENTION
The present invention relates to a method for promoting fat loss. More
particularly, the invention relates to co-administration of hydroxycitrate,
carnitine and a compound which increases mitochondrial synthesis of oxaloacetate.
BACKGROUND OF THE INVENTION
More specifically, the conversion of cytoplasmic fatty acyl coA to fatty acyl
carnitine via the enzyme carnitine palmitoyl transferase I (CPT) is pace-setting
for fatty acid transport into mitochondria and thus for ketogenesis in which
fatty acids are oxidized (McGarry et al., supra.). HCA, the main acid found in
fruits of the genus Garcinia, disinhibits CPT by suppressing synthesis of
malonyl coA, a key allosteric inhibitor of this enzyme. Carnitine is the
essential cofactor for CPT activity, and ordinary non-fasting hepatocyte levels
of this enzyme appear to be subsaturating, such that provision of extra
carnitine accelerates hepatic ketogenesis when CPT is activated.
There is a constant need for methods of promoting weight and fat loss. The
present invention provides such a method.
SUMMARY OF THE INVENTION
The present invention also provides a pharmaceutical composition comprising
hydroxycitrate, carnitine and an agent which promotes the rapid
intramitochondrial generation of oxaloacetate or induces endogenous production
of pyruvate, wherein the ratio of hydroxycitrate to carnitine to agent is
between about 2:1:2 and 10:1:100 (w/w). Preferably, the agent which promotes
rapid intramitochondrial generation of oxaloacetate is pyruvate, lactic acid,
aspartic acid, serine or glycine. Advantageously, the agent which promotes
endogenous production of pyruvate is metformin or biotin.
Patent
A patent for an invention is the grant of a property right to the inventor,
issued by the Patent and Trademark Office. The term of a new patent is 20 years
from the date on which the application for the patent was filed in the United
States. The Ketone
™ patent formula was filed in 1997, and the inventor was
awarded a legal monopoly that extends to the year 2017. The patent grants the
patent owner the right to exclude others from making, using, selling, or
offering to sell the invention throughout the U.S., or importing the invention
into the U.S., and the right to exclude others from using, selling, or offering
to sale throughout the U.S., or importing into the U.S., products made by that
process. 35 U.S.C. 154.
Future Bodies, Incorporated, and its principals have gone through great lengths and
extraordinary measures to procure the Ketone formula patent. Future Bodies,
Incorporated, is fully intent on protecting it against any infringement to the
full extent of the law. If the patent is infringed, Future Bodies, Incorporated,
will sue for relief in the appropriate federal court. Future Bodies,
Incorporated, will ask the court for an injunction to prevent the continuation
of the infringement and will also ask the court for an award of damages because
of the infringement. In such an infringement suit, it does not matter for
liability purposes that a patented infringer was unaware of the patented
technology when infringement occurred. However, the money damages amount may be
tripled if the infringement is found to be "willful."
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