Garcinia Mangosteen

“Queen of Fruits”

MANGOSTEEN
Garcinia Mangostana L., family Clusiaceae (Guttiferae)

Mangosteen (Garcinia mangostana L.) is known as the “Queen of Fruits”. Its origin is in Southeast Asia, probably the Malay Archipelago. It can now be found in Northern Australia, Brazil, Burma, Central America, Hawaii, Southern India, Indonesia, Malaysia, Siri Lanka, Thailand, Vietnam, and other tropical countries. Mangosteen is one of the most widely recognized tropical fruits and has universal appeal because of its quality in color, shape and flavor. Demand often exceeds supply. The fruit is 2-3 in (cm) in diameter. A thick reddish-purple rind covers the aril or pulp which is segmented like that of an orange. The white, moist, soft and juicy flesh is sweet and aromatic, has a high sugar content, but is low in vitamins and minerals. It is usually eaten fresh, but can be stored successfully for short periods of time. It is also canned, frozen, or made into juice, preserves, and syrup. Mangosteen is also used as a pharmaceutical (Kanchanapoom and Kanchanapoom, 1998; Martin, 1980; Nakasone and Paull, 1998).
No other tropical fruit has been so highly praised as the Mangosteen. The combination of beautiful coloring and interesting shape with a delicate, enticing flavor ranks it above all other fruit of the Asiatic tropics. The Mangosteen has none of the insipid flavor ascribed to many tropical fruits, and it is almost universally liked by the individuals tasting it for the first time.

Purported by many who have had the luxury of tasting it as being the best tasting fruit in the world. While possibly a bit extreme, the Mangosteen is instantly liked by many who eat it. The soft flesh, resembling a bright white tangerine, has a deep grape-strawberry like flavor that melts in the mouth. Unfortunately, its high popularity, extreme growing conditions, and restrictions on importation to the United States, find the fresh fruit nonexistent outside the tropics.

Origin and Distribution

The place of origin of the Mangosteen is unknown but is believed to be the Sunda Islands and the Moluccas; still, there are wild trees in the forests of Kemaman, Malaya. Corner suggests that the tree may have been first domesticated in Thailand, or Burma. It is much cultivated in Thailand–where there were 9,700 acres (4,000 ha) in 1965–also in Kampuchea, southern Vietnam and Burma, throughout Malaya and Singapore. The tree was planted in Ceylon about 1800 and in India in 1881. There it succeeds in 4 limited areas–the Nilgiri Hills, the Tinnevelly district of southern Madras, the Kanya-kumani district at the southernmost tip of the Madras peninsula, and in Kerala State in southwestern India. The tree is fairly common only in the provinces of Mindanao and Sulu (or Jolo) in the Philippines. It is rare in Queensland, where it has been tried many times since 1854, and poorly represented in tropical Africa (Zanzibar, Ghana, Gabon and Liberia). There were fruiting trees in greenhouses in England in 1855. The Mangosteen was introduced into Trinidad from the Royal Botanic Garden at Kew, England, between 1850 and 1860 and the first fruit was borne in 1875. It reached the Panama Canal Zone and Puerto Rico in 1903 but there are only a few trees in these areas, in Jamaica, Dominica and Cuba, and some scattered around other parts of the West Indies. The United States Department of Agriculture received seeds from Java in 1906 (S.P.I. #17146). A large test block of productive trees has been maintained at the Lancetilla Experimental Station at Tela, Honduras, for many years. Quite a few trees distributed by the United Fruit Company long ago have done well on the Atlantic coast of Guatemala. In 1924, Dr. Wilson Popenoe saw the Mangosteen growing at one site in Ecuador. In 1939, 15,000 seeds were distributed by the Canal Zone Experiment Gardens to many areas of tropical America. It is probable that only a relatively few seedlings survived. It is known that many die during the first year. Dr. Victor Patiño has observed flourishing Mangosteen trees at the site of an old mining settlement in Mariquita, Colombia, in the Magdalena Valley and the fruits are sold on local markets. Dierberger Agricola Ltda., of Sao Paulo, included the Mangosteen in their nursery catalog in 1949.

Despite early trials in Hawaii, the tree has not become well acclimatized and is still rare in those islands. Neither has it been successful in California. It encounters very unfavorable soil and climate in Florida. Some plants have been grown for a time in containers in greenhouses. One tree in a much protected coastal location and special soil lived to produce a single fruit and then succumbed to winter cold.

The rind of partially ripe fruits yields a polyhydroxy-xanthone derivative termed Mangostin, also ß-mangostin. That of fully ripe fruits contains the xanthones, gartanin, 8-disoxygartanin, and normangostin. A derivative of Mangostin, mangostin-e, 6-di-O-glucoside.

 

What are xanthones?

Xanthones are a class of chemical compounds, similar to vitamins, in that xanthones help the body’s cells to function correctly and optimally. A xanthone is composed of 3 diamond shaped rings resembling a part of a honey comb. Carbon and oxygen atoms make of the atomic backbone ... seen in the following figure:

 


Chemical Name: [2,4'-Bi-9H-xanthene]-9,9'-dione, 2'-.beta.-D-glucopyranosyl-1,1',3',4,6',7',8-heptahydroxy-6-methoxy-

What do the xanthones in the pericarp of the mangosteen fruit do?


There are over 40 known xanthones in the pericarp of the mangosteen fruit. There are also polysaccharides and other active chemicals that give the mangosteen fruit its medicinal properties. The following is a short list outlining some of these benefits:

Anti-inflammatory – is known to inhibit swelling, tenderness, edema and pain.
Antioxidant – known to stop the harmful effects of free radicals in the body.
Cholesterol – inhibits the oxidation of LDL (the bad) cholesterol before it has a chance to damage the lining of an artery can cause a plaque to build up. In other words, reduces the risk of atherosclerosis.
Immune system – possess potent anti-bacterial, anti-viral and anti-fungal properties.
Antitumor properties – the xanthones from mangosteen inhibited growth of different types of liver cell cancer and showed promise with pancreatic cancer.
Digestive system – demonstrated anti-ulcer activity and helped the body overcome diarrhea and dysentery.
Anti-allergic – demonstrated to reduce the effects of allergic reactions of the body from common allergens to anaphylaxis.
Central nervous system – the mangosteen is shown to produce a therapeutic effect in both the treatment and prevention of Parkinson’s and Alzheimer’s disease
Skin – demonstrated to reduce the effects of dermatitis, eczema and skin infections.
 

 

Can One get xanthones from simply eating food?

No. The xanthone family of phytonutrients are found primarily in two families in nature ... Guttiferae (the family of the mangosteen) and Gentianaceae. The pericarp of the mangosteen is a premier source where xanthones are found in concentrated amounts. Many scientific studies name the mangosteen pericarp as one of the main sources of xanthones in nature. There are (so far) over 40 identified xanthones in the pericarp of the mangosteen fruit.

How come we haven’t heard about xanthones before?

Xanthones are very restricted in occurence. The majority of natural xanthones have been found in just two families of higher plants ... Guttiferae (the family of the mangosteen) and Gentianaceae. The Guttiferae family contains over 1000 known species of plants that mainly confined to the tropics. The major exception to this is St. Johns Wort.

 

Is there any current research data to support how effective Xanthones are as compared to Vitamin A, C, E and other antioxidants i.e. lycopene combined?

Several xanthones have been used in experiments as antioxidants to protect LDL, the "bad cholesterol", from being oxidized. In those studies alpha tocopherol (one of the forms of vitamin E) was used as a comparison and the xanthone was "more effective than the vitamin E at preventing the oxidation of LDL". Catechins, the same elements as contained in green tea are also present in significant amounts in mangosteen. These substances in studies have been shown to be more potent as antioxidants than vitamin C.

 

What is the best delivery system for xanthones? Can one obtain enough healthy benefits by simply drinking one of the many commercial juice products, such as "Xango"?

 

The most effective way to take in Xanthones would be from a Garcinia Mangosteen Extract that has been prepared with the proper drying method and concentration. We only know of one such product on the market aptly named "Mangosteen Xanthone Extract" from Future Bodies. The benefits of such a product are assurance of a high concentration of xanthones, proper absorption without the sugar and excess carbohydrates of the "xango" juice. As of the time of this writing it is still unknown just how many xanthones if any are in the commercially prepared drinks.

Future Bodies Incorporated has the only known Mangosteen Xanthone extract in capsule form. 500 mg at 25% strength yields the highest ORAC rating per single dose.

Historical Medicinal Uses:
Dried fruits are shipped from Singapore to Calcutta and to China for medicinal use. The sliced and dried rind is powdered and administered to overcome dysentery. Made into an ointment, it is applied on eczema and other skin disorders. The rind decoction is taken to relieve diarrhea and cystitis, gonorrhea and gleet and is applied externally as an astringent lotion. A portion of the rind is steeped in water overnight and the infusion given as a remedy for chronic diarrhea in adults and children. Filipinos employ a decoction of the leaves and bark as a febrifuge and to treat thrush, diarrhea, dysentery and urinary disorders. In Malaya, an infusion of the leaves, combined with unripe banana and a little benzoin is applied to the wound of circumcision. A root decoction is taken to regulate menstruation. A bark extract called "amibiasine", has been marketed for the treatment of amoebic dysentery.
 

 

 

Claims
· Antioxidant protection against free radicals
· Maintains immune system health
· Promotes joint flexibility
· Provides positive mental support
· Reduces allergies
· Reduces joint inflammation
· Prevents cancer
 

 

 

Theory
The human body produces free radicals during everyday life. Free radicals are atoms or groups of atoms with an odd number of (unpaired) electrons. Free radicals are very unstable and react quickly with other compounds. Once formed, free radicals can start a chain reaction of cell damage finally resulting in death of the cell. Antioxidants, such as vitamins A, C, and E, and selenium, are chemicals found in whole foods (especially fruits and vegetables) that help to protect the body's cells from the harmful effects of free radicals. Xanthone is a compound found in mangosteen fruit that may have antioxidant properties.

 

 

Future Bodies Incorporated has the only known Mangosteen Xanthone extract in capsule form. 500 mg at 25% strength yields the highest ORAC rating per single dose.

 


 Thaigo by Natures Sunshine. This Multi Level Marketing product is in juice form and sells for over $70.00 plus shipping for 2 bottles. Xanthone content per bottle or serving is unspecified.


Essential Vitamins Plus Mangosteen from New Vision is essentially Aloe Vera with added vitamins and unspecified amount of Mangosteen. The Product purports dangerously high anti-oxidant and ORAC ratings over 60,000 the amount of healthy levels. Have they heard of "Hypervitaminosis"? $33.95 for 25 ounces.

 

 


Xango juice $39.95 for 25 ounces. Xanthone level or dose unspecified. It is suspected that the intensive heat pasteurization process that most of the Mangosteen drinks have gone through has destroyed the beneficial compounds of the fruit.

 

 

 

 

 

Pharmacodynamics

PubMed Gamma-mangostin shifts rightward the dose/response curve for 5-HT induced aorta contraction without affecting contractile responses to KCl, phenylephrine or histamine Chairungsrilerd 1998

PubMed Salmonella is inhibited and PMN phagocytes stimulated by polysaccharides from mangosteen pericarp Chanarat 1997

PubMed Histamine & serotonin induced aorta contraction was inhibited by a methanolic extract of Garcinia mangostana fruit hulls. Alpha-Mangostin is a competitive histamine H1 receptor antagonist. Gamma-mangostin is a competitive 5-HT2A receptor antagonist Furukawa 1997

PubMed Anti-fungal activity of xanthones and mangostin from Garcinia mangostana fruit hulls Gopalakrishnan 1997

PubMed Alpha-mangostin and gamma-mangostin appear to be histaminergic and a serotonergic receptor blocking agents, respectively Chairungsrilerd 1996

PubMed HIV-1 protease is inhibited by Garcinia mangostana ethanol extract, due to mangostin (IC50 = 5.1 microM) and gamma-mangostin (IC50 = 4.8 microM) Chen 1996

PubMed Alpha-mangostin, a xanthone derivative from G. mangostana, inhibits methicillin-resistant Staphylococcus aureus, MIC = 1.6 -12.5 micrograms/ml. Rubraxanthone from G. dioica is more active, MIC = 0.3-1.2 micrograms/ml Iinuma 1996

PubMed Low density lipoprotein oxidation is inhibited by mangostin dose dependently at 5 - 50 microM Williams 1995

PubMed "Antimicrobial activities of Garcinia Mangostana " (no abstract) Sundaram 1983

 

 

Analytical Chemistry

PubMed Garm FatA1, an acyl-acyl carrier protein thioesterase from G. mangostana, generates elevated stearate (18:0) in transgenic Brassica plants. Mutants were created that generate even higher levels of stearate Calgene1999

PubMed Acyl-ACP thioesterases specific for each of the saturated acyl-ACP substrates from 8:0 through 16:0 have been cloned. 18:1-ACP specificity was found with G. mangostana acyl-ACP thioesterase. Mangosteen seed oil accumulates to 56% 18:0 (stearate) Hawkins 1998

PubMed 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H- xanthen-9-one (mangostin) and 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)- 9H-xanthen-9-one (gamma-mangostin) in fruit hulls Jinsart 1992

 

Animal Studies

PubMed Gamma-mangostin from Garcinia mangostana fruit hull injected (10-40 nmol/mouse) inhibited 5FMT induced head-twitch response and inhibits accumulation of inositol phosphates indicating it to be a 5-HT2A receptor antagonist Chairungsrilerd 1998

PubMed "Effect of mangostin, a xanthone from Garcinia mangostana Linn. in immunopathological & inflammatory reactions " (no abstract) Gopalakrishnan 1980

PubMed Mangostin and derivatives are CNS depressant (ptosis, sedation, decreased motor activity, potentiation of pentobarbital sleeping time & ether anaesthesia) and anti-inflammatory in mice and rats. No analgesic, antipyretic nor anticonvulsant effects Shankaranarayan 1979