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Garcinia Mangosteen |
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“Queen of Fruits”
MANGOSTEEN
Origin and Distribution |
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What is the best delivery system for xanthones? Can one obtain enough healthy benefits by simply drinking one of the many commercial juice products, such as "Xango"?
The most effective way to take in Xanthones would be from a Garcinia Mangosteen Extract that has been prepared with the proper drying method and concentration. We only know of one such product on the market aptly named "Mangosteen Xanthone Extract" from Future Bodies. The benefits of such a product are assurance of a high concentration of xanthones, proper absorption without the sugar and excess carbohydrates of the "xango" juice. As of the time of this writing it is still unknown just how many xanthones if any are in the commercially prepared drinks. |
Future Bodies Incorporated has the only known Mangosteen Xanthone extract in capsule form. 500 mg at 25% strength yields the highest ORAC rating per single dose.
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Historical Medicinal Uses:
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Claims
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Theory
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Pharmacodynamics
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Analytical Chemistry PubMed Garm FatA1, an acyl-acyl carrier protein thioesterase from G. mangostana, generates elevated stearate (18:0) in transgenic Brassica plants. Mutants were created that generate even higher levels of stearate Calgene1999 PubMed Acyl-ACP thioesterases specific for each of the saturated acyl-ACP substrates from 8:0 through 16:0 have been cloned. 18:1-ACP specificity was found with G. mangostana acyl-ACP thioesterase. Mangosteen seed oil accumulates to 56% 18:0 (stearate) Hawkins 1998 PubMed 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H- xanthen-9-one (mangostin) and 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)- 9H-xanthen-9-one (gamma-mangostin) in fruit hulls Jinsart 1992 |
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Animal Studies PubMed Gamma-mangostin from Garcinia mangostana fruit hull injected (10-40 nmol/mouse) inhibited 5FMT induced head-twitch response and inhibits accumulation of inositol phosphates indicating it to be a 5-HT2A receptor antagonist Chairungsrilerd 1998 PubMed "Effect of mangostin, a xanthone from Garcinia mangostana Linn. in immunopathological & inflammatory reactions " (no abstract) Gopalakrishnan 1980 PubMed Mangostin and derivatives are CNS depressant (ptosis, sedation, decreased motor activity, potentiation of pentobarbital sleeping time & ether anaesthesia) and anti-inflammatory in mice and rats. No analgesic, antipyretic nor anticonvulsant effects Shankaranarayan 1979 |
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